It would be good to have guides that could be used just like in every other popular design tool like photoshop, fireworks, illustrator, etc.
Those guides could react by changing the screen size. Why not implementing grids and gutters? Check out http://www.macaw.co
I like their clever solution for this.
Please check out the help section on Smart Guides - http://support.antetype.com/solution/articles/1000075620-smart-guides
But I am not sure if this is directly what you are looking for, you may want to experiment a bit with the Antetype layouting system because working with this is not the same as designing on a grid - the system will relayout as you change widths etc.
If you want an example that does work with a grid you could check out this example: http://cotype.antetype.com/show-details/layout-grid-widget
Or read this post: http://www.antetype.com/blog/2013/04/grid-layouts-bootstrap/